This case examines a universal question: How can a tech startup (such as an AI or big data startup) address the pain points of traditional vertical industries through technological innovation and create value? Some tech startups set ambitious goals, which demand significant and sustained investments in R&D, but fail to plan for commercial development in order to remain viable: when funding runs out, they go bust. Explore Chinabased-companies profile at Times of India for photos, videos and latest news of Chinabased-companies. Others aim for low-hanging fruit in more easily accessible markets, at the expense of pursuing their original goal once engaged on this path, it is extremely difficult to change course and build an iconic name. The LinkDoc Technology (hereinafter 'LinkDoc') case was compiled as one way to find answers to these questions. Medical data group LinkDoc Technology Ltd in July became the first Chinese company to shelve plans for an IPO in the United States due to Beijings clampdown on overseas listings by domestic firms. The issue, then, is how tech startups should strike a balance between "aiming too high" and "taking a faster route." The LinkDoc Technology (hereinafter "LinkDoc") case was compiled as one way to find answers to these questions. Chinese fitness app Keep, podcasting platform Ximalaya, medical solution provider LinkDoc reportedly canceled their US IPO plans after Didi debacle.Details: Keep did not go ahead with its planned public filing while its bankers at Morgan Stanley canceled marketing meetings with investors this week, Financial Times reported, citing people familiar with the matter. Rise of Nations, from Brian Reynolds, designer of Civilization II, and Big Huge Games, offers players the chance to span 6,000 years of history-from the Ancient Age to the Information Age-and engage in trade, espionage, diplomacy, and war.The case examines how LinkDoc, specializing in big data and serving the vertical healthcare industry, found its own answers to these issues and, more specifically, how it identified and entered its target market segment, and. The GameSpot Complete Game Guide for Rise of Nations includes: This comprehensive GameSpot Complete Game Guide for Rise of Nations provides everything an aspiring leader needs to achieve global domination. Economic Strategies: This section covers Rise of Nations economic strategies, including resource management, the importance of hotkeys, expansion keys, and running an efficient economy.The section also includes a rundown of the rare resources and their benefits. New Jersey needs a new senator who will work independently to make Washington work better for us and not the other way around. As a fellow Republican who happens to be transgender, I believe that Mr. Combat Strategies: Look here for Rise of Nations combat strategies, including the importance of counter units and combined arms, combat stances, and scouting, as well as an array of combat tips covering flanking, control groups, modern warfare, generals, spies, and attrition. Chinabased keep linkdoc us ipotimes Hugin nj senate Hugin nj senate.Nation Overviews: This section covers all 18 nations and describes each nation's benefits, unique units, and tactics.The Library, Ages, and Wonders: This section offers insight into three important Rise of Nations concepts: the research-filled library, advancing through the ages, and the magnificent-and quite beneficial-wonders.Military Civic Commerce Science Advancing Ages Wonders Technologies Conquer the World Strategies Multiplayer Strategies Multiplayer Strategies: This section provides strategies for success in a Rise of Nations multiplayer game.Conquer the World Strategies: This section provides strategies specific to the Rise of Nations "conquer the world" campaign game.Technologies: Head here for a table revealing important Rise of Nations technologies, including research locations and each technology's benefits. This section covers Rise of Nations' six resources and how to manage them, the importance of learning hotkeys, expansion techniques, and running an efficient economy. A sound economy is the foundation for a successful game of Rise of Nations. Without a flourishing economy, a player will struggle to research important technologies, advance through the ages, and create a substantial military force.Įffective and efficient resource management is at the heart of most real-time strategy games. If you're able to collect more resources than your opponent in a shorter amount of time, you're likely to have better technology and a stronger military. This section elaborates on Rise of Nations' six primary resources and offers tips on juggling the commerce limit and improving gathering.īuild farms to gather food. Cities can support up to five farms, unless you're the Egyptians, and then your cities can support seven.įood Gather food by building farms.
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Rita had written Bathilda a very cheerful thank you note and had it sent to her, either just before, or at the time that the real Bathilda was killed by Voldemort, and she was taken over by his snake, Nagini. While under the influence of Veritaserum, Bathilda unwittingly provided her with background information of Dumbledore himself, and Grindelwald, her great nephew. Not long after the release of Rita Skeeter's book, she had a copy sent to one of her most valuable sources for the most vulgar and interesting lies and half-truths provided, Bathilda Bagshot. Rita" - The note Rita Skeeter left attached to the copy of the book she sent to Bathilda Bagshot You said everything, even if you don't remember it. Here's a copy of the book, hope you like it. This, of course, was also a promotional piece, as the interview was published before the book was released. Īn article concerning The Life and Lies of Albus Dumbledore was published in the Daily Prophet, which was supplemented by an interview with Rita Skeeter about her views on her book. Harry, though angry, did acknowledge the fact that Dumbledore and Grindelwald had once been friends, based on a copy of the letter Dumbledore wrote being printed inside the book. Some people, such as Ron's Auntie Muriel, praised Skeeter, while others, such as Elphias Doge and Harry Potter, were furious over Skeeter's conspicuous attempt to impugn Dumbledore's character Doge went as far as to state that the book "contain less fact than a Chocolate Frog Card". Skeeter's book was widely discussed and opinions toward it were polarised. I am ashamed to say that I became rather rude, called her an interfering trout, which resulted, as you may have seen, in aspersions cast upon my sanity." Harry Potter: " Well, in that interview, Rita Skeeter hinted that Professor Dumbledore was involved in the Dark Arts when he was young." Elphias Doge: " Don’t believe a word of it! Not a word, Harry! Let nothing tarnish your memories of Albus Dumbledore!" Muriel: " Rita Skeeter? Oh, I love her, always read her!" - Harry Potter, Elphias Doge and Muriel discussing the book's controversial contents īack cover of the book, featuring the author Rita Skeeter That woman, or vulture might be a more accurate term, positively pestered me to talk to her. Harry Potter: " Elphias, I don’t know whether you saw the interview Rita Skeeter gave about Dumbledore?" Elphias Doge: " Oh, yes, Harry, I saw it. In the article, Rita comments that the chapter is based on the speculation that Harry may have been involved with Dumbledore's murder. In a sneak peek in the Daily Prophet, Rita says that there is a whole chapter on the Dumbledore/ Potter relationship. It also talked about how Dumbledore's father was imprisoned in Azkaban for attacking three Muggles, and explored Dumbledore's relationship in his younger days with Gellert Grindelwald, who would later become an immensely powerful Dark wizard, second only in power to Voldemort, and would be defeated in 1945 by Dumbledore himself. The book contained some controversial, though partially true, revelations about Dumbledore and his family, for example, the story of covering up of the " sickness" of Dumbledore's sister Ariana. One of the pages of the book, featuring Gellert GrindelwaldĪ page behind the page on top with Albus Dumbledore and Gellert Grindelwald It is probably because of this "warmth and softness" that Braithwaite's write-up was highly favourable and quite heavily biased in favour of Skeeter. Prior to its release, Betty Braithwaite had visited Rita's home for an interview about the title, and Rita served her tea and a slice of pound cake. The book was rated with five stars by the Daily Prophet. Īs was her common tendency, Rita made sure the book was released in the immediate wake of a death to ensure that public interest in the person she was doing a book on remained high, whilst fully exploiting the legal situation that the dead cannot be libelled. It was published in late July or early August of that year. Though it ran nine-hundred pages in length, Skeeter completed the book only four weeks after Dumbledore's death in June 1997. The Life and Lies of Albus Dumbledore was a biography of Albus Dumbledore that was written by Rita Skeeter. " Stripping away the popular image of serene, silver-bearded wisdom, Rita Skeeter reveals the disturbed childhood, the lawless youth, the lifelong feuds and the guilty secrets Dumbledore carried to his grave." - Description of the book Really: You can do lying hamstring curls, seated hamstring curls, and standing hamstring curls all at an LA Fitness. The floor layout typically includes a vast selection of weight machines that allow you to hit any muscle you can think of from any angle. Like Gold’s Gym, LA Fitness is another commercial gym that caters to bodybuilders and anyone looking to perform hypertrophy-focused (muscle-building) workouts. This is definitely more than a simple gym membership and is best for those who want more of a lifestyle integration, rather than just a simple place to hit the weights. A membership also lends itself to exclusive events, such as rooftop fitness classes at One World Observatory in New York City and cooking classes with famous chefs.Įquinox membership fees vary based on which club you attend and how many clubs and amenities you have access to: more clubs plus more amenities equal a higher fee. If you can handle the base price of $200 or more per month, you’ll get access to cold eucalyptus towels, a full-service spa, a lifestyle shop, unlimited group classes, steam rooms, saunas, and more. Equinox is known for its high-end amenities, high-quality equipment, modern interior design, and sleek branding-and it had an eye-widening monthly membership price tag to match. If you enjoy the finer things in life, you’ll probably feel very at home in one of the 100-plus Equinox locations around the U.S. This is often the price you pay for convenience and availability. Your home Anytime Fitness might be fantastically clean and have functional equipment, but another across the country might not. The only real downside to Anytime Fitness is that it’s a fast-growing chain, which can present discrepancies in franchise quality. The membership fees won’t hurt your wallet as much as some commercial gym chains, either: The average monthly fee is about $41. Most Anytime Fitness locations have all of the space and equipment you need for a good workout, including barbells and racks, dumbbells, kettlebells, boxes, cardio equipment, weight machines, and yoga mats. This unique travel-friendly feature (plus the more than 4,700 franchises) makes Anytime Fitness a great gym membership option for people who often find themselves in different parts of the country, whether they travel for business or for leisure. On top of that, Planet Fitness offers a schedule of free fitness training seven days per week: If you aren’t sure where to start, attend one of these small group training sessions for no extra cost.Īnytime Fitness offers a unique amenity that most commercial gyms-even 24-hour ones-don’t: your very own key fob to enter the gym at any time of day or night, without needing a gym employee there to let you in. There are rules in place about dropping weights, yelling, grunting, and doing other things that typically make fellow gym-goers uncomfortable called the Lunk Alarm. If you’re new to fitness and feel intimidated by gyms, Planet Fitness is a great place to get your feet wet. It strives to make everyone feel welcome, no matter what level of fitness they're at. Planet Fitness has also become renowned for its “Judgement Free Zone” policy. The Black Card membership also gives you unlimited access to spas at all locations that have them. and bring a friend for free every time you visit. If you’re willing to pay $14.99 more for the PF Black Card membership for a total of $24.99 per month, you can get access to all 2,400+ locations in the U.S. For just $10 per month, members can access virtually all types of cardio machines, basic weight machines, floor space, dumbbells, and barbells-everything you need to work up a good sweat. On the end of the gym spectrum opposite Equinox, Planet Fitness is known for its inclusivity, simplicity, and small price tag. The number in Box 3 should not be higher than $137,700. Learn more about Social Security and Medicare taxes. It helps pay for the retirement, disability, and survivorship benefits that millions of Americans receive each year. This figure will also include compensation like pre-tax contributions to 401(k), 403(b) annuity, SIMPLE-IRA and 457 government retirement plans. This is how much of your total wages are subject to Social Security tax. If you’ve paid too much, you’ll get a nice refund, but if you’ve paid too little, you will owe taxes for the year. The IRS compares this withheld amount with the total amount of taxes you owe, to see if you’ve paid too much or too little. It’s based on your total taxable wages for the year, and the filing status on your W-4, which you filled out when you were hired. This is the amount of federal income tax that has been withheld from your wages and sent to the IRS this year. If you received paid sick leave, or paid family leave under the Families First Coronavirus Response Act (FFCRA), wages for this paid leave will appear here. If your Box 1 wages are lower than your Box 3 wages, it may be because you have pre-tax benefits that are exempt from federal income tax, but not Social Security tax. If you see that this figure is higher or lower than other wages on your W-2, that’s okay. But there are also exceptions, including pre-tax retirement plan contributions, Section 125 health insurance premiums, and commuter benefits that are deducted from your gross pay, before any taxes are taken out. Most compensation is taxed, including compensation that isn’t money, like personal use of a company car, or 2% shareholders health insurance premiums. This is a total of all your wages, tips, and any other compensation you’ve received this year, before any taxes or deductions have been taken out. You’ll need this information when preparing your tax return, so the IRS requires your employer to postmark your W-2 no later than January 31.īut what do all these boxes mean? And how do you know it’s right? 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You can check which other mice are Flow enabled here.I'm running version 10.12.6 of macOS Sierra on a 2013 MacBook Pro. You will need to install Logi Options+ software on both computers and follow these instructions. You can even copy and paste between computers. The MX Keys keyboard will follow the mouse and switch computers at the same time. You can use the mouse cursor to move from one computer to the next. With a Flow-enabled Logitech mouse, such as MX Master 3, you can work and type on multiple computers with the same mouse and keyboard using Logitech Flow technology. You can work on multiple computers with your MX Keys keyboard. NOTE: By default, the keyboard has direct access to Media Keys. We’ve added a notification to let you know you’ve swapped. Press Fn + Esc to swap between Media keys and F-Keys. When your keyboard reaches 10% of battery left, backlighting turns OFF and you get a battery notification on the screen. You will see this notification when you try to turn backlighting ON. This will also allow you to use it longer with backlight in low light conditions. When the environment around you is too bright, your keyboard will automatically disable backlighting to avoid using it when not needed. If you want backlight back, plug your keyboard to charge. When your keyboard has only 10% of battery left when you try to enable backlighting, this message will appear. There are two factors that will disable backlighting: Click /optionsplus for more information.Ĭhange the backlight level and to know in real-time what level you have. Install Logitech Options+ software to get the most out of your keyboard. The keyboard battery is low (below 10%).The room brightness is high (above 200 lux).You can change the backlight levels at any time, with two exceptions: the backlight cannot be turned ON when: Your keyboard has an embedded ambient light sensor that reads and adapts the level of backlighting accordingly. You can continue typing while it is charging. Plug the USB-C cable at the top right corner of your keyboard. You can continue typing for more than 500 hours without backlighting when the battery is low. Your keyboard will let you know when it is running low. To download and learn more about the possibilities go to /optionsplus.Ĭlick here for the list of supported OS versions for Options+.Ĥ - Battery status LED and ambient light sensor Once paired, a short press on the Easy-Switch button will allow you to switch channels.ĭownload Logi Options+ to use all the possibilities this keyboard has to offer.USB receiver: Plug the receiver to a USB port, open Logitech Options, and select: Add devices > Setup Unifying device, and follow the instructions.Bluetooth: Open the Bluetooth settings on your computer to complete the pairing.To connect your keyboard to your computer:.This will put the keyboard in discoverable mode so that it can be seen by your computer. Select the channel you want and press and hold the Easy-Switch button for three seconds.Your keyboard can be paired with up to three different computers using the Easy-Switch button to change the channel. PAIR TO A SECOND COMPUTER WITH EASY-SWITCH To download and learn more, go to /optionsplus. If you experience issues with Bluetooth, click here for Bluetooth troubleshooting.ĭownload Logi Options+ to use all the possibilities this keyboard has to offer. Open the Bluetooth settings on your computer to complete the pairing.Ĭlick here for more details on how to do this on your computer. Plug the receiver into a USB port on your computer. If you are working on a desktop, we recommend using the USB receiver. If you need more information, click here. If you have FileVault enabled, we recommend using a Logitech USB receiver to use your mouse. When enabled, it might prevent Bluetooth® devices from connecting with your computer if you have not yet logged in. NOTE: If the LED is not blinking quickly, perform a long press (three seconds).įileVault is an encryption system available on some Mac computers. The number 1 LED on the keyboard should blink quickly. If you want more in-depth information, go to the ‘Detailed Setup’ below. Go to the interactive setup guide for quick interactive setup instructions. Brie is a lawyer who is smart, hard-charging, ballsy and a whole lot of fun. Zibby Allen (The Flash, Grey’s Anatomy) is a new series regular who plays Brie, Jack's sister. Several new faces are set to arrive in Virgin River season 3. David Cubitt as Calvin, a man who runs an illegal pot farm.Chase Petriw as Mike Valenzuela, a former Marine who served with Jack.Lynda Boyd as Lilly, a friend of Connie's.Gwynyth Walsh as Jo Ellen, owner of the town B&B.Daniel Gillies as Mark Monroe, Mel's late husband seen in flashbacks.Jenny Cooper as Joey Barnes, Mel's older sister who lives in Los Angeles.Nicola Cavendish as Connie, owner of the town's general store.Sarah Dugdale as Lizzie, Connie's niece from Los Angeles.Grayson Gurnsey as Ricky, a young man who works at Jack's Bar.Benjamin Hollingsworth as Dan Brady, a former Marine who served with Jack.Lauren Hammersley as Charmaine Roberts, Jack's ex-romantic interest.Annette O'Toole as Hope McCrea, the mayor of Virgin River and Doc's separated wife.Tim Matheson as Vernon "Doc" Mullins, MD, the town doctor.Colin Lawrence as John "Preacher" Middleton, Jack's friend and bartender who is a former Marine. The cast of Virgin River season 3 is led by Alexandra Breckenridge as Melinda "Mel" Monroe, a nurse practitioner and midwife originally from Los Angeles.Īlongside her is Martin Henderson as Jack Sheridan, a restaurant/bar owner and former U.S. "I just end up breaking things."īut make sure to watch to the end of the clip, because Jack and Mel tell each other "I love you"! Virgin River season 3 cast "Getting emotional doesn’t really work for me,” Jack says. Netflix also dropped a sneak peek clip of Virgin River season 3, titled "Smashing Stuff." (opens in new tab) Jack and Mel are discussing everything he's been through, and she notes that she has cried and yelled to deal with the bad things that have happened to her. Oh, and there's the fact that his ex Charmaine is expecting their twin babies any day now. But is he truly ready to start a family? After all, he's still recovering from being shot and his relationship with Mel is still new. “If you’re smart, you’ll give that lady a ring and start a family,” one townsperson advises Jack of Mel. The official trailer for Virgin River season 3 is burning with baby fever. Virgin River was so popular, it even dethroned The Crown (opens in new tab) from the Nielsen streaming rankings and even topped The Mandalorian (opens in new tab) at one point. The streamer renewed the show in December 2020, just weeks after the second season premiered. Season 3 will consist of 10 episodes, which all drop at at the same time. "That's a huge thing for a person to go and do.Netflix is releasing Virgin River season 3 on Friday, July 9 at 3 a.m. "She wants a baby so badly that she goes to the fertility clinic and gets inseminated with her dead husband's sperm," Breckenridge reiterated to E! News. It wasn't entirely clear if she went through with it until that finale admission, and now we're genuinely wondering about Mel's sanity and wellbeing. She and Jack briefly broke up in the middle of the season, and it sent Mel running to LA and the clinic where her dead husband's frozen sperm were being kept. Season four (assuming there is one) is going to either be really sweet or really weird.īasically, Mel ( Alexandra Breckenridge) is pregnant, and the father is either Jack or her dead husband. In fact, this cliffhanger might actually have much bigger ramifications than Jack ( Martin Henderson) being shot in his kitchen, depending on the directions the writers decide to take this in. The Netflix drama has returned for season three, and once again it ends on a shocking note, even if no one's in danger of dying (at least, we hope not). Virgin River is back, and it may have truly outdone itself. The cost of wedding flowers will vary wildly and depend on a number of factors - all of which we detail in this article. What Impacts the Cost of Wedding Flowers?.Giving expert advice and invaluable insight into what goes on behind the scenes as a wedding florist, here is the ultimate guide to wedding flower prices, as told by the experts themselves. With the help of seven UK wedding florists, we've gathered everything you need to know about the average cost of wedding flowers, what impacts the price of wedding flowers, and exactly what you can expect to get for each price bracket. Wedding Flower Prices: How Much Does It Cost & Why? To ensure you get the best bang for your buck, whilst maintaining realistic and fair expectations, we've put together a guide to wedding flower costs and prices in the UK. Having said that, there are so many affordable wedding florists out there, including ones that cater specifically to smaller wedding budgets, as well as those who specialise in high-end events. If you think your wedding florist quote is expensive, that's because wedding flowers genuinely can be expensive - not because someone's added a zero as soon as they find out you're getting married. It's a common misconception that anything with the word 'wedding' attached to it doubles in price, but that is so far from the truth. To do this, you need to understand what impacts the cost, and how florists determine each quote. However, for couples trying to plan their wedding budget, it's important to become more familiar with wedding flower prices and ultimately determine what their cost of wedding flowers will be. Wedding flower orders span from simple rose bouquets, to full-blown floral wedding arches and instalments, so pinpointing an average cost of wedding flowers in the UK is close to impossible. We offer any color palette and style.When it comes to how much wedding flowers cost, there is so much to consider. This saves our couples labor costs to install this onsite as well as delivery fees. We also offer dried wedding arch flowers that you can keep for years! We ship them straight to your door, already designed and easy to attach to your arch yourself. We ask our couples what their priorities are with the flowers from the gecko, as well as what their flower budget is, to then put together the best game plan when allocating the flowers. The more elaborate the arch, the more expensive it will become. It also of course has to do with what types of flowers you are wanting. There is a wide range when it comes to the arch flower prices depending on if you just want a small spray of flowers in the corner of the arch, or if you want flowers all the way around the entire arch. On average, traditional wedding arches cost $150-$250 to rent the arch itself (depending on what style of arch you’re wanting). If your florist does not provide an arch, ask them if they have any recommendations on where you can rent one from in your area. This is because there are so many factors that can change it including, budget, flowers choices, greenery usage. So just because the arch looks one way in the photo provided does not mean it will look like that during your wedding. But, we will be honest, every wedding arch design is different. We recommend asking your florist for images of the arch they have for rent, and for images of it in use. People are using any large type of structure for their arches, and all of them have the creative potential to look unique and align with your wedding vision. There are many different styles ranging from the classic traditional arch shape to circles and hexagons. The first arch-related questions to ask your florist is if they do have one for rent, and what kind/shape it is, and how much is it to rent for just the arch itself.Īrches come in many shapes, sizes and materials. Welcome to Merck’s First Quarter 2023 conference call. Peter Dannenbaum, Vice President, Investor Relations. I would now like to turn the call over to Mr. At this time, all participants are in a listen-only mode until the question-and-answer session of today’s conference. Welcome to the Merck and Company Q1 Sales and Earnings Conference Call. Trung Huynh - Credit Suisse - Analyst Presentation: Malcolm Hoffman - BMO Capital Markets - Analystĭaina Graybosch - SVB Securities - Analyst Li, M.D., Ph.D. - Executive Vice President and President, Merck Research Laboratories Analysts:Ĭhris Shibutani - Goldman Sachs - Analyst Davis - Chairman and Chief Executive OfficerĬaroline Litchfield - Executive Vice President and Chief Financial Officerĭean Y. Peter Dannenbaum - Vice President, Investor Relations (NYSE: MRK) Q1 2023 Earnings Call dated Apr. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.Merck & Co., Inc. The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. The study authors’ full disclosures can be found at. Hyun Cheol Chung, MD, PhD, of the Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, is the corresponding author for the Journal of Clinical Oncology article.ĭisclosure: The study was supported by Merck Sharp & Dohme, a subsidiary of Merck & Co. Food and Drug Administration granted accelerated approval of pembrolizumab for patients with advanced PD-L1–positive cervical cancer who experienced progression during or after chemotherapy.” The investigators concluded, “Pembrolizumab monotherapy demonstrated durable antitumor activity and manageable safety in patients with advanced cervical cancer. No treatment-related deaths were reported. The most common immune-mediated adverse events of any grade were hypothyroidism (11.2%) and hyperthyroidism (9.2%). Immune-mediated adverse events occurred in 25.5% of patients, with grade 3 or 4 events occurring in 5.1% (hepatitis in 2 patients, severe skin reaction in 2 patients, and adrenal insufficiency in 1 patient). Treatment-related adverse events led to discontinuation of treatment in 4 patients (4.1%). Treatment-related grade 3 or 4 adverse events occurred in 12.2% of patients, with the most common being increased alanine transaminase (3.1%). Treatment-related adverse events of any grade occurred in 65.3% of patients, with the most common being hypothyroidism (10.2%), decreased appetite (9.2%), and fatigue (9.2%). Median overall survival was 9.4 in the total population vs 11.0 months in the PD-L1–positive population. Median progression-free survival was 2.1 months in both the entire population and the PD-L1–positive population. Median duration of response was not reached (range = ≥ 3.7 to ≥ 18.6 months), with response in 7 patients lasting ≥ 12 months at time of analysis. In the PD-L1–positive group, median time to response was 2.1 months. All responses occurred among the 82 patients with PD-L1–positive tumors (response rate = 14.6%), and 11 responses occurred among the 77 of these patients (14.3%) who had received ≥ 1 line of chemotherapy for recurrent or metastatic disease. Objective response was observed in 12 patients (12.2%), including 3 with complete response. Eighty-two patients (83.7%) had PD-L1–positive tumors (combined positive score ≥ 1), and 77 in the PD-L1–positive group had previously received ≥ 1 line of chemotherapy for recurrent or metastatic disease. Patients had a median age of 46 years (range = 24–75 years). The primary endpoint was objective response rate on RECIST v1.1 assessed by independent central radiologic review. Tumor imaging was performed every 9 weeks for the first 12 months, and then every 12 weeks thereafter. These patients received pembrolizumab 200 mg every 3 weeks for 2 years or until progression, intolerable toxicity, or physician or patient decision. The current report is an interim report on the cohort of 98 patients with previously treated advanced cervical cancer. KEYNOTE-158 is a basket trial in multiple cancer types. The study supported the 2018 accelerated approval of pembrolizumab in this setting.
The FreeStyle Libre 14-day system will be available via prescription in the coming months at participating pharmacies and durable medical equipment suppliers (DMEs) in the U.S.įreeStyle Libre system is now being used by more than 800,000 people across more than 43 countries 8 and is the #1 CGM worldwide 9. The FreeStyle Libre system (10 day) was approved by the FDA in September 2017. The FreeStyle Libre 14-day system has a 1-hour warmup and greater accuracy compared to the FreeStyle Libre system (10 day) with a mean absolute relative difference (MARD) of 9.4 compared to 9.7, respectively. The FreeStyle Libre system is supported by both clinical data 5,6 and real-world evidence 7 that show that people who scan more frequently spend less time in hypoglycemia (low-glucose levels) or hyperglycemia (high-glucose levels) while having improved average glucose levels, demonstrating improved glucose control overall. The sensor is worn on the back of the upper arm and is the size of two stacked quarters. With just a quick, one-second scan, users can see real-time glucose readings, as well as identify glucose trends with a directional arrow and review eight hours of glucose history. In the U.S., the FreeStyle Libre system (10 day) is approved for replacement 2 of blood glucose monitoring (BGM) for adults with diabetes. The FreeStyle Libre system, which first launched in Europe in 2014, with a 14-day wear time, was the first to eliminate the need for fingersticks 10, and is designed to be an easier-to-use 2, streamlined 3 and more affordable system4 compared with other available CGMs on the market. "With the new FreeStyle Libre 14-day system, people with diabetes will now have extended access to their glucose data with a high degree of accuracy, which will improve their experience and help empower them to better manage their condition." "At Abbott, we are continuously pushing for new innovations that minimize the daily burden of managing diabetes," said Jared Watkin, senior vice president, Diabetes Care, Abbott. This approval makes Abbott's revolutionary continuous glucose monitor (CGM) the longest lasting self-applied personal glucose sensor available on the market. Food and Drug Administration (FDA) has approved the FreeStyle Libre 14 day Flash Glucose Monitoring system, which allows people with diabetes to wear the sensor up to 14 days with high accuracy.
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